ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 16 Issue : 1 Year : 2024
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Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Long-term Survival in a Child with Malignant Insulinoma After Liver Transplantation [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2024; 16(1): 106-110 | DOI: 10.4274/jcrpe.galenos.2022.2022-3-5

Long-term Survival in a Child with Malignant Insulinoma After Liver Transplantation

Elzbieta Moszczynska1, Arnika Wydra2, Klaudia Zasada1, Marta Baszynska-wilk1, Dorota Majak3, Anna Sliwinska4, Wieslawa Grajkowska5
1The Children’s Memorial Health Institute, Department of Endocrinology and Diabetology, Warsaw, Poland
2Bielański Hospital, Center of Postgraduate Medical Education, Department of Endocrinology, Warsaw, Poland
3The Children’s Memorial Health Institute, Department of Diagnostic Imaging, Warsaw, Poland
4The Children’s Memorial Health Institute, Department of Nuclear Medicine, Warsaw, Poland
5The Children’s Memorial Health Institute, Department of Pathology, Warsaw, Poland

Insulinoma is one of the pancreatic neuroendocrine tumors (PanNET) and is exceptionally rare in children. The tumor leads to severe hypoglycemia caused by excessive insulin release. We report a pediatric patient with malignant insulinoma who underwent liver transplantation (LT) due to liver metastases of the insulinoma. A 13-year-old girl presented with symptoms of hypoglycemia due to hyperinsulinism. On computed tomography (CT), a polycystic lesion in the head of the pancreas and enlarged lymph nodes were revealed. A modified Whipple’s operation was performed, and histological examination confirmed PanNET. CT also showed an enlarged liver with numerous metastases. Allogeneic LT was carried out successfully. Positron emission tomography-CT using 68Ga-DOTA-labeled somatostatin analogs (SSAs) at the age of 22 years confirmed complete metabolic remission. The patient currently remains under immunosuppressive and anti-proliferative treatment. Multiple surgical interventions, LT combined with SSAs, and immunosuppressive medication proved effective in this case of metastatic malignant insulinoma.

Keywords: Hypoglycemia, insulinoma, liver transplantation, children

Corresponding Author: Marta Baszynska-wilk, Poland
Manuscript Language: English
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