ISSN: 1308-5727 | E-ISSN: 1308-5735
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Turkish Society for Pediatric Endocrinology and Diabetes
Vitamin D Deficiency in Children and Adolescents with Type 1 Diabetes [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2011; 3(4): 179-183 | DOI: 10.4274/jcrpe.430

Vitamin D Deficiency in Children and Adolescents with Type 1 Diabetes

Ajda Mutlu1, Gül Yeşiltepe Mutlu2, Elif Özsu2, Filiz Mine Çizmecioğlu2, Şükrü Hatun2
1Kocaeli University, Medical Faculty, Department Of Pediatrics, Kocaeli, Turkey
2Kocaeli University, Medical Faculty, Department Of Pediatrics, Division Of Pediatric Endocrinology And Diabetes, Kocaeli, Turkey

Objective: To investigate the frequency and effects of vitamin D deficiency in children with type 1 diabetes (T1D) in a region which is known to have a high rate of vitamin D deficiency among adolescents.
Met­hods: In this prospective cross-sectional study, 120 children and adolescents with T1D (55 girls and 65 boys) aged 3-20 years were evaluated. Serum 25-hydroxyvitamin D [25(OH)D], parathormone (PTH), and alkaline phosphatase (ALP) levels were measured. Hemoglobin A1c levels and daily insulin requirement were also evaluated. Classification of vitamin D status was made according to the American Academy of Pediatrics (AAP)/LWEPS’s recommendations. The patients were divided into 2 groups according to their vitamin D status and also according to the season of the year in which 25(OH)D sampling was done.
Re­sults: Serum 25(OH)D levels revealed vitamin D deficiency or insufficiency in 38% of the patients. Higher PTH levels were found in the patient group whose mean 25(OH)D level was <20 ng/mL as compared to the group whose mean 25(OH)D level was >20 ng/mL (p<0.05).
Only 11% of patients had secondary hyperparathyroidism. The 25(OH)D levels of patients whose serum samples were taken in summer and spring months were significantly different (p<0.05). There were no significant correlations between 25(OH)D level and daily insulin dose.
Conc­lu­si­on: Although we could not show a significant association between vitamin D deficiency and metabolic parameters, the frequency of vitamin D deficiency in T1D children is substantial. Vitamin D status should be assessed also in patients who do not have signs of rickets.

Keywords: Vitamin D,type 1 diabetes,children and adolescents

Ajda Mutlu, Gül Yeşiltepe Mutlu, Elif Özsu, Filiz Mine Çizmecioğlu, Şükrü Hatun. Vitamin D Deficiency in Children and Adolescents with Type 1 Diabetes. J Clin Res Pediatr Endocrinol. 2011; 3(4): 179-183
Manuscript Language: English
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