ISSN: 1308-5727 | E-ISSN: 1308-5735
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Turkish Society for Pediatric Endocrinology and Diabetes
Plasma Kisspeptin Levels in Newborn Infants with Breast Enlargement [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2015; 7(3): 192-196 | DOI: 10.4274/jcrpe.1994

Plasma Kisspeptin Levels in Newborn Infants with Breast Enlargement

Avni Kaya1, Zerrin Orbak1, Harun Polat2, Atilla Çayır1, Abdullah Erdil1, Hakan Döneray1
1Atatürk University Faculty Of Medicine, Department Of Pediatric Endocrionology, Erzurum, Turkey
2Atatürk University Faculty Of Medicine, Department Of Biochemistry, Erzurum, Turkey

Objective: Kisspeptin levels have been reported in children with premature thelarche, precocious puberty and adolescent gynecomastia, but there are no reports on kisspeptin levels in the neonatal period. This study aimed to investigate plasma kisspeptin hormone levels in newborns with and without breast enlargement.
Methods: Plasma kisspeptin levels and other related biochemical variables were investigated in this prospective study conducted on 40 (20 girls and 20 boys) newborn infants with breast enlargement and on 40 healthy control infants (20 girls and 20 boys). Two-milliliter venous blood samples were taken in hemogram tubes with K2EDTA. Kisspeptin assays were performed using the enzyme-immunoassay method.
Results: Mean plasma kisspeptin levels were 0.6±0.2 ng/mL in the study group and 0.5±0.2 ng/mL in the control group. Plasma kisspeptin concentrations were significantly higher in the study group (p=0.039) and also showed a correlation with serum prolactin levels (p=0.006). Significant correlations were also determined between plasma kisspeptin and luteinizing hormone concentrations (p=0.05, r=0.312).
Conclusion: The findings of this study suggest that plasma kisspeptin and serum prolactin levels may be involved in the physiopathology of breast enlargement in newborns.

Keywords: Kisspeptin,newborn,breast enlargement

Avni Kaya, Zerrin Orbak, Harun Polat, Atilla Çayır, Abdullah Erdil, Hakan Döneray. Plasma Kisspeptin Levels in Newborn Infants with Breast Enlargement. J Clin Res Pediatr Endocrinol. 2015; 7(3): 192-196
Manuscript Language: English
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