ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : Issue : Year : 2022
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Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Hemolytic Anemia due to Glucose 6 Phosphate Dehydrogenase Deficiency Triggered by Type 1 Diabetes Mellitus [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-35744 | DOI: 10.4274/jcrpe.galenos.2021.2021-11-10

Hemolytic Anemia due to Glucose 6 Phosphate Dehydrogenase Deficiency Triggered by Type 1 Diabetes Mellitus

Burçe Orman1, Semra Çetinkaya1, Nergiz Öner2, Meltem Akçaboy3, Ali Fettah2, Naz Güleray Lafcı4, Şenay Savaş Erdeve1
1Department of Pediatric Endocrinology, Dr. Sami Ulus Obstetrics and Gynecology, Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey
2Department of Pediatric Hematology, Dr. Sami Ulus Obstetrics and Gynecology, Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey
3Department of Pediatrics, Dr. Sami Ulus Obstetrics and Gynecology, Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey
4Department of Genetics, Hacettepe University, Ankara, Turkey

Glucose 6 phosphate dehydrogenase (G6PD) is expressed in all tissues and is necessary for the oxidant stress capacity of cells. G6PD deficiency is the most common enzymopathy in humans; it is among the important causes of hemolytic anemia. It has been reported that severe hemolytic anemia due to G6PD deficiency may develop in newly diagnosed diabetes, especially during the correction of hyperglycemia. To date, 9 cases have been described in the literature. Genetic analysis was not performed for G6PD deficiency in patients in the literature. We present a case of hemolytic anemia due to G6PD deficiency secondary to newly diagnosed diabetes.Genetic testing was performed for the index patient and revealed a previously reported missense pathogenic variant (c.653C>T; p.Ser218Phe) in G6PD gene.

Keywords: diabetes mellitus, G6PD, anemia



Corresponding Author: Burçe Orman, Türkiye
Manuscript Language: English
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