ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 3 Issue : 2 Year : 2023
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Turkish Society for Pediatric Endocrinology and Diabetes
Thyroid Functions in Long-Term Survivors of Pediatric Hodgkin’s Lymphoma Treated with Chemotherapy and Radiotherapy [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2011; 3(2): 89-94 | DOI: 10.4274/jcrpe.v3i2.18

Thyroid Functions in Long-Term Survivors of Pediatric Hodgkin’s Lymphoma Treated with Chemotherapy and Radiotherapy

Metin Demirkaya1, Betül Sevinir1, Halil Sağlam2, Lütfi Özkan3, Okan Akacı4
1Division Of Pediatric Oncology, Department Of Pediatrics, Uludag University, Medical Faculty, Bursa, Turkey
2Division Of Pediatric Endocrinology, Department Of Pediatrics, Uludag University, Medical Faculty, Bursa, Turkey
3Department Of Radiation Oncology, Uludag University, Medical Faculty, Bursa, Turkey
4Department Of Pediatrics, Uludag University, Medical Faculty, Bursa, Turkey\R\N

Objective: Post-treatment endocrine disturbances are common in cancer patients who have received radiotherapy or chemotherapy. The objective of this study was to evaluate the thyroid functions of long-term survivors of pediatric Hodgkin’s lymphoma treated with chemotherapy and radiotherapy.
Methods: Thyroid functions of 55 Hodgkin’s lymphoma patients (M/F: 2.05/1) in complete remission were evaluated retrospectively.
Results: The mean age of the patients at diagnosis was 10.35±4.09 (range: 2.83-17) years and the mean follow-up period was 5.54±3.68 (range: 0.92-13.92) years. All patients received chemotherapy; a total of 50 patients (90.9%) underwent radiotherapy, 42 (76.4%) of whom received neck/mantle radiotherapy. Thyroid function tests were abnormal in 14 (24.5%) patients and normal - in the remaining 41 (74.5%). A diagnosis of subclinical and overt hypothyroidism was made in 11 (78.6%) and 3 (21.4%) patients with abnormal thyroid function tests, respectively. Nearly one-fourth (21.4%) of all thyroid function disorders were detected in the first year of follow-up. A statistically significant correlation was found between the dose of mantle radiotherapy and thyroid function disorder (p=0.002). In addition, statistically significant correlations were established between thyroid examination or thyroid ultrasonography findings and thyroid functions (p <0.001 or p=0.006, respectively).
Conclusions: Radiation-induced thyroid disorders may develop in pediatric Hodgkin’s lymphoma patients in complete remission starting as early as the first year after treatment and are dose-dependent. Patients, particularly those who have been exposed to radiotherapy of the neck, must be followed up closely for occurrence of thyroid dysfunctions.

Keywords: Hodgkin disease,children,late effect

Metin Demirkaya, Betül Sevinir, Halil Sağlam, Lütfi Özkan, Okan Akacı. Thyroid Functions in Long-Term Survivors of Pediatric Hodgkin’s Lymphoma Treated with Chemotherapy and Radiotherapy. J Clin Res Pediatr Endocrinol. 2011; 3(2): 89-94
Manuscript Language: English
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