ISSN: 1308-5727 | E-ISSN: 1308-5735
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Turkish Society for Pediatric Endocrinology and Diabetes
Cardiac Function in Newborns with Congenital Hypothyroidism: Association with Thyroid-Stimulating Hormone Levels [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2015; 7(4): 307-311 | DOI: 10.4274/jcrpe.1969

Cardiac Function in Newborns with Congenital Hypothyroidism: Association with Thyroid-Stimulating Hormone Levels

Taliha Öner1, Rahmi Özdemir1, Önder Doksöz1, Yılmaz Yozgat1, Cem Karadeniz1, Savaş Demirpençe1, Murat Muhtar Yılmazer1, Muammer Büyükinan2, Timur Meşe1, Vedide Tavlı1
1Dr. Behçet Uz Children’S Hospital, Clinic Of Pediatric Cardiology, İzmir, Turkey
2Konya Training And Research Hospital, Clinic Of Pediatric Endocrinology, Konya, Turkey

Objective: The aims of this study were to demonstrate ventricular function changes in patients with congenital hypothyroidism and to investigate whether there is an association between any such changes and thyroid-stimulating hormone (TSH) levels using M-mode and Doppler electrocardiography (ECG) and tissue Doppler imaging (TDI).
Methods: Twenty-seven patients 5-30 days of age with congenital hypothyroidism who were scheduled to receive L-thyroxine treatment and 20 healthy newborns were included in this study. Twelve-lead ECG and M-mode TDI recordings of the patient and healthy groups were obtained. The patient group was divided into two subgroups according to TSH level (>100 uIU/mL or <100 uIU/mL), which were then compared on all parameters.
Results: Decreases were observed in the ejection fraction (EF), shortening fraction (SF), and mitral lateral annulus, mitral septal annulus, and tricuspid lateral annulus systolic velocity (Sa) on TDI, whereas left ventricular end-systolic diameter (LVESd) and corrected QT interval (QTc) dispersion were significantly increased in the patient group compared with the control group. No significant differences between the groups were found in left ventricular end-diastolic diameter (LVEDd) or heart rate. When the two patient subgroups (TSH >100 uIU/mL and <100 uIU/mL) were compared, TDI septal annulus Sa wave length and heart rate were significantly lower in the TSH >100 group.
Conclusion: Impairment in left ventricular systolic function and increased risk of arrhythmia were observed in newborn infants with congenital hypothyroidism. TSH level was associated with heart rate and interventricular septum velocity.

Keywords: newborn,congenital hypothyroidism,cardiac functions

Taliha Öner, Rahmi Özdemir, Önder Doksöz, Yılmaz Yozgat, Cem Karadeniz, Savaş Demirpençe, Murat Muhtar Yılmazer, Muammer Büyükinan, Timur Meşe, Vedide Tavlı. Cardiac Function in Newborns with Congenital Hypothyroidism: Association with Thyroid-Stimulating Hormone Levels. J Clin Res Pediatr Endocrinol. 2015; 7(4): 307-311
Manuscript Language: English
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