Genetics of Growth Hormone Deficiency

From the initiation of the primordium to the expression of mature growth hormone (GH)1 gene, a variety of genes, transcription factors, signalling pathways, and epigenetic control factors take part in the embryological development of the anterior hypophyseal somatotrophic cells. A defect in this process may result in multiple pituitary deficiency or isolated growth hormone deficiency depending on the temporal or spatial position of the individual factor. This article reviews these factors in a chronological order. This review presents some of these genetic mutations that result in obesity.