ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 7 Issue : 3 Year : 2024
Forms

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Effects of Diabetic Ketoacidosis on Visual and Verbal Neurocognitive Function in Young Patients Presenting with New-Onset Type 1 Diabetes [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2015; 7(3): 203-210 | DOI: 10.4274/jcrpe.2158

Effects of Diabetic Ketoacidosis on Visual and Verbal Neurocognitive Function in Young Patients Presenting with New-Onset Type 1 Diabetes

Ashley B. Jessup1, Mary Beth Grimley2, Echo Meyer2, Gregory P. Passmore3, Ayşenil Belger2, William H. Hoffman4, Ali S. Çalıkoğlu1
1University Of North Carolina At Chapel Hill Faculty Of Medicine, Division Of Pediatric Endocrinology, North Carolina, United States Of America
2University Of North Carolina At Chapel Hill Faculty Of Medicine, Department Of Psychiatry, North Carolina, United States Of America
3Georgia Regents University (Formerly Georgia Health Sciences University), Medical Laboratory, Imaging And Radiological Sciences, Georgia, United States Of America
4Georgia Regents University, Department Of Pediatric Endocrinology And Diabetes, Georgia, United States Of America

Objective: To evaluate the effects of diabetic ketoacidosis (DKA) on neurocognitive functions in children and adolescents presenting with new-onset type 1 diabetes.
Methods: Newly diagnosed patients were divided into two groups: those with DKA and those without DKA (non-DKA). Following metabolic stabilization, the patients took a mini-mental status exam prior to undergoing a baseline battery of cognitive tests that evaluated visual and verbal cognitive tasks. Follow-up testing was performed 8-12 weeks after diagnosis. Patients completed an IQ test at follow-up.
Results: There was no statistical difference between the DKA and non-DKA groups neither in alertness at baseline testing nor in an IQ test at followup. The DKA group had significantly lower baseline scores than the non-DKA group for the visual cognitive tasks of design recognition, design memory and the composite visual memory index (VMI). At follow-up, Design Recognition remained statistically lower in the DKA group, but the design memory and the VMI tasks returned to statistical parity between the two groups. No significant differences were found in verbal cognitive tasks at baseline or follow-up between the two groups. Direct correlations were present for the admission CO2 and the visual cognitive tasks of VMI, design memory and design recognition. Direct correlations were also present for admission pH and VMI, design memory and picture memory.
Conclusion: Pediatric patients presenting with newly diagnosed type 1 diabetes and severe but uncomplicated DKA showed a definite trend for lower cognitive functioning when compared to the age-matched patients without DKA.

Keywords: diabetic ketoacidosis,Cognition,dehydration,neuroinflammation

Ashley B. Jessup, Mary Beth Grimley, Echo Meyer, Gregory P. Passmore, Ayşenil Belger, William H. Hoffman, Ali S. Çalıkoğlu. Effects of Diabetic Ketoacidosis on Visual and Verbal Neurocognitive Function in Young Patients Presenting with New-Onset Type 1 Diabetes. J Clin Res Pediatr Endocrinol. 2015; 7(3): 203-210
Manuscript Language: English
LookUs & Online Makale