J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-47450 | DOI: 10.4274/jcrpe.galenos.2024.2024-2-18

Frequency of Delayed Puberty in Boys with Contemporary Management of Duchenne Muscular Dystrophy

Sarah McCarrison¹, Melissa Denker¹, Jennifer Dunne³, Iain Horrocks³, Jane McNeilly⁴, Shuko Joseph³, Sze Choong Wong^1
1Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow
²Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow and Department of Human Nutrition, University of Glasgow
³Department of Paediatric Neurology, Royal Hospital for Children, Glasgow
⁴Department of Biochemistry, Queen Elizabeth University Hospital, Glasgow, United Kingdom

INTRODUCTION: Delayed puberty is thought to be common in boys with Duchenne muscular dystrophy (DMD) treated with long term oral glucocorticoid. This study aims to report the frequency of delayed puberty in DMD from examination by a paediatric endocrinologist alongside detailed endocrine investigations.
METHODS: All boys with DMD aged at least 14 years in January 2022 known to the paediatric neuromuscular service (2016-2022) were included in this study. Delayed puberty was defined based on testicular volume and genital staging in comparison to published puberty nomogram.
RESULTS: Twenty-four out of 37 boys (65%) had evidence of delayed puberty, 23/24 (96%) of those with delayed puberty were on glucocorticoid therapy all of whom were on daily glucocorticoid. On the other hand, 7/13 (54%) of those with normal timing of puberty were on glucocorticoid; 2/7 (29%) were on the intermittent regimen. Of those who were on daily glucocorticoid therapy at the time of assessment of puberty, 23/28 (82%) had evidence of delayed puberty. In boys with delayed puberty, endocrine investigations showed low luteinizing hormone (LH) with undetectable testosterone levels, a pre-pubertal response with lutenizing hormone releasing hormone test and sub-optimal testosterone levels with prolonged human chorionic gonadotropin stimulation.
DISCUSSION AND CONCLUSION: The frequency of delayed puberty in boys with DMD was 65%. Eighty-two percent of adolescent boys with DMD on daily glucocorticoid had evidence of delayed puberty. Biochemical investigations point to functional central hypogonadism in these adolescents. Our data supports the routine monitoring of puberty in boys with DMD.

Keywords: Delayed puberty, Hypogonadism, Glucocorticoid, Deflazacort, Prednisolone

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