ISSN: 1308-5727 | E-ISSN: 1308-5735
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Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
J Clin Res Pediatr Endocrinol. 2020; 12(2): 130-139 | DOI: 10.4274/jcrpe.galenos.2019.2019.0176
2Klinikum der Universität München, Medizinische Klinik und Poliklinik IV, Endocrine Research Laboratories, Munich, Germany
A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure
Jan M. Wit1, Martin Bidlingmaier2, Christiaan de Bruin1, Wilma Oostdijk11Leiden University Medical Center, Department of Paediatrics, Leiden, The Netherlands2Klinikum der Universität München, Medizinische Klinik und Poliklinik IV, Endocrine Research Laboratories, Munich, Germany
The serum insulin-like growth factor-I (IGF-I) concentration is commonly used as a screening tool for growth hormone deficiency (GHD), but there is no consensus on the cut-off limit of IGF-I standard deviation score (SDS) to perform GH stimulation tests for confirmation or exclusion of GHD. We argue that the cut-off limit is dependent on the clinical pre-test likelihood of GHD and propose a diagnostic strategy in which the cut-off limit varies between zero to -2 SDS.
Keywords: Short stature, growth disorders, IGF-I, IGFBP-3Jan M. Wit, Martin Bidlingmaier, Christiaan de Bruin, Wilma Oostdijk. A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure. J Clin Res Pediatr Endocrinol. 2020; 12(2): 130-139
Manuscript Language: English
Manuscript Language: English
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