ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 6 Issue : 4 Year : 2024
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Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Importance of Insulin Immunoassays in the Diagnosis of Factitious Hypoglycemia [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2014; 6(4): 258-261 | DOI: 10.4274/jcrpe.1492

Importance of Insulin Immunoassays in the Diagnosis of Factitious Hypoglycemia

Özlem Nalbantoğlu Elmas1, Korcan Demir1, Nusret Soylu2, Nilüfer Çelik3, Behzat Özkan1
1Dr. Behçet Uz Children’S Hospital, Clinic Of Pediatric Endocrinology, İzmir, Turkey
2Children’S Hospital, Clinic Of Child And Adolescent Psychiatry, Gaziantep, Turkey
3Dr. Behçet Uz Children’S Hospital, Division Of Biochemistry, İzmir, Turkey

We report two cases emphasizing the importance of insulin assays for evaluation of hypoglycemia in diabetic patients. Case 1 was a 96/12-year-old female patient with type 1 diabetes mellitus and case 2 was a 1010/12-year-old male patient with DIDMOAD. Both patients were on a basal-bolus insulin regimen. Both were admitted because of persistent hypoglycemia. Analyses of serum samples obtained at the time of hypoglycemia initially showed low insulin and C-peptide levels. Recurrent episodes of unexplained hypoglycemia necessitated measurement of insulin levels by using different insulin assays, which revealed hyperinsulinemic hypoglycemia with low C-peptide levels, findings which confirmed a diagnosis of factitious hypoglycemia. Surreptitious administration of insulin should not be excluded in diabetic patients with hypoglycemia without taking into account the rate of cross-reactivity of insulin analogues with the insulin assay used.

Keywords: type 1 diabetes mellitus,DIDMOAD,factitious hypoglycemia,recurrent hypoglycemia,insulin assay

Özlem Nalbantoğlu Elmas, Korcan Demir, Nusret Soylu, Nilüfer Çelik, Behzat Özkan. Importance of Insulin Immunoassays in the Diagnosis of Factitious Hypoglycemia. J Clin Res Pediatr Endocrinol. 2014; 6(4): 258-261
Manuscript Language: English
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