ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 1 Issue : 2 Year : 2024
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Turkish Society for Pediatric Endocrinology and Diabetes
Atherogenic Lipid Profile and Systolic Blood Pressure are Associated with Carotid Artery Intima-media Thickness in Children with Turner Syndrome [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2008; 1(2): 62-71 | DOI: 10.4008/jcrpe.v1i2.9

Atherogenic Lipid Profile and Systolic Blood Pressure are Associated with Carotid Artery Intima-media Thickness in Children with Turner Syndrome

Özgür Pirgon1, Mehmet Emre Atabek1, Bülent Oran1, Rıdvan Güçlü2
1Division of Pediatric Endocrinology, Faculty of Medicine, Selcuk University, Konya, Turkey
2Division of Pediatric Endocrinology, Faculty of Medicine, Selcuk University, Konya, Turkey

Objective: Women with Turner syndrome (TS) have greater carotid artery intima-media thickness (cIMT) known to be a risk factor for atherosclerosis in adults. To determine whether there are risk factors for atherosclerosis in children with TS, we compared cIMT, anthropometric and metabolic parameters between children with TS and healthy controls.
Methods: Data of children with TS with XO karyotype (n=24, mean age: 11.6±3.6) were compared with those of healthy children (n=24, mean age: 10.5±3.6) with respect to anthropometric parameters, lipid levels, insulin resistance and cIMT which was measured by high resolution B-mode ultrasonography.
Results: Mean age and cIMT values were similar in the two groups of children. However in children with TS, fasting glucose (p=0.01), total cholesterol (p=0.006), triglyceride (p=0.04) levels and HDL-cholesterol (p=0.002) levels were higher than those of controls. In the TS group, cIMT correlated positively with LDL-cholesterol (r=0.435, p=0.034) and with systolic blood pressure (r=0.430, p=0.036) and negatively with HDL-cholesterol (r=-0.518, p=0.01). In stepwise regression analysis, HDL-cholesterol emerged as a significant predictor of cIMT (b= -0.518, p=0.01) contributing to 26.8 % of its variability.
Conclusion: The systolic blood pressure and dyslipidaemia were shown to be risk factors for atherosclerosis in children with TS.

Keywords: Turner syndrome, children, cardiovascular disease, carotid intima-media thickness

Atherogenic Lipid Profile and Systolic Blood Pressure are Associated with Carotid Artery Intima-media Thickness in Children with Turner Syndrome

Özgür Pirgon1, Mehmet Emre Atabek1, Bülent Oran1, Rıdvan Güçlü2
1Division of Pediatric Endocrinology, Faculty of Medicine, Selcuk University, Konya, Turkey
2Division of Pediatric Endocrinology, Faculty of Medicine, Selcuk University, Konya, Turkey


Özgür Pirgon, Mehmet Emre Atabek, Bülent Oran, Rıdvan Güçlü. Atherogenic Lipid Profile and Systolic Blood Pressure are Associated with Carotid Artery Intima-media Thickness in Children with Turner Syndrome. J Clin Res Pediatr Endocrinol. 2008; 1(2): 62-71
Manuscript Language: English
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