ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 15 Issue : 4 Year : 2023
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Turkish Society for Pediatric Endocrinology and Diabetes
Pulse Wave Analysis in Obese Children with and without Metabolic Syndrome [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2023; 15(4): 397-405 | DOI: 10.4274/jcrpe.galenos.2023.2022-10-21

Pulse Wave Analysis in Obese Children with and without Metabolic Syndrome

Cemaliye Başaran1, Gökçen Erfidan1, Özgür Özdemir-Şimşek1, Seçil Arslansoyu-çamlar2, Demet Alaygut2, Fatma Mutlubaş2, Cem Karadeniz3, Bumin Nuri Dündar4, Belde Kasap-Demir6
1University Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Pediatrics, Division of Nephrology, İzmir, Turkey
2University Health Sciences Turkey, İzmir Faculty of Medicine, Department of Pediatrics, Division of Nephrology, İzmir, Turkey
3İzmir Katip Çelebi University Faculty of Medicine, Department of Pediatrics, Division of Cardiology, İzmir, Turkey
4İzmir Katip Çelebi University Faculty of Medicine, Department of Pediatrics, Division of Endocrinology, İzmir, Turkey
5İzmir Katip Çelebi University Faculty of Medicine, Department of Pediatrics, Division of Nephrology and Rheumatology, İzmir, Turkey
6University Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Pediatrics, Division of Nephrology, İzmir, Turkey and İzmir Katip Çelebi University Faculty of Medicine, Department of Pediatrics, Division of Nephrology and Rheumatology, İzmir, Turkey

INTRODUCTION: To compare pulse wave analysis (PWA) of obese children with and without metabolic syndrome (MS) with healthy, non-obese children and to evaluate the association between PWA findings and additional risk factors present in children with MS and obesity.
METHODS: From the obese patients examined between June 2019 and June 2021, 41 patients with MS, 36 obese patients without MS, and 34 healthy non-obese children of similar age and gender were evaluated retrospectively. Anthropometric measurements, biochemical evaluation, 24-hour ambulatory blood pressure (BP) measurement (ABPM), left ventricular mass index (LVMI) and PWA measurements were compared.
RESULTS: When the three groups were compared, weight standard deviation score (SDS), height SDS and body mass index SDS were all significantly higher in the MS group (p<0.05). The following measurements were significantly higher in both MS and non-MS obese patients compared to the control group: from ABPM measures, the systolic and mean arterial pressure BP SDSs load; from PWA, the night central systolic BP, 24-hour, day and night pulse pressure values and 24-hour, day and night pulse wave velocity (PWV) rates; and from cardiac evaluations, the LVMI and relative wall thickness measurements (all p<0.05). Furthermore, the 24-hour and daytime central systolic (cSBP) and diastolic BP (cDBP) values were significantly different between the three groups, being the highest in the MS group (p<0.05).
DISCUSSION AND CONCLUSION: Obesity causes higher office, ambulatory and central BP, PWV and LVMI. However our results suggest that additional risk factors associated with MS do not contribute to these parameters, except for 24-hour and daytime cSBP and cDBP values.

Keywords: Children, pulse wave analysis, metabolic syndrome, obesity

Cemaliye Başaran, Gökçen Erfidan, Özgür Özdemir-Şimşek, Seçil Arslansoyu-çamlar, Demet Alaygut, Fatma Mutlubaş, Cem Karadeniz, Bumin Nuri Dündar, Belde Kasap-Demir. Pulse Wave Analysis in Obese Children with and without Metabolic Syndrome. J Clin Res Pediatr Endocrinol. 2023; 15(4): 397-405

Corresponding Author: Cemaliye Başaran, Türkiye
Manuscript Language: English
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