ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 4 Issue : 2 Year : 2024
Forms

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2012; 4(2): 76-81 | DOI: 10.4274/Jcrpe.547

Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents

Derya Taşkesen1, Birgül Kirel2, Tercan Us3
1Eskişehir Osmangazi University Hospital, Department Of Pediatrics, Eskişehir, Turkey
2Eskişehir Osmangazi University Hospital, Pediatric Endocrinology Unit, Eskişehir, Turkey
3Eskişehir Osmangazi University Hospital, Department Of Microbiology, Eskişehir, Turkey

Objective: Visfatin, an adipokine, has insulin-mimetic effects. The main determinants of both the production and the physiologic role of visfatin are still unclear. The aim of this study is to determine the relation of serum visfatin to adiposity and glucose metabolism.
Methods: 40 pubertal adolescents (20 females, 20 males; age range: 9-17 years) with exogenous obesity and 20 age- and sex-matched healthy adolescents (10 females, 10 males) were enrolled in the study. Oral glucose tolerance test (OGTT) was performed in the obese group. Serum glucose, insulin and visfatin levels were analyzed in the fasting state in the controls and at 0, 60 and 120 minutes during the OGTT in the obese group.
Results: The obese group had higher serum visfatin levels than the control group [11.6 (3.3-26) ng/mL vs. 7.5 (3.3-10.5) ng/mL, p<0.001]. Visfatin levels were correlated positively with body mass index, waist/hip ratio, insulin, and homeostasis model assessment for insulin resistance and negatively with glucose/insulin ratio in the combined group (obese subjects plus controls). Visfatin levels were essentially similar in obese subjects with and without insulin resistance (p>0.05). Serum visfatin levels did not change at 60 and 120 minutes of the OGTT compared to the baseline levels (p>0.05).
Conclusions: Serum visfatin levels are elevated in obese adolescents and do not change with acute changes in glucose metabolism. Visfatin levels are related with adiposity and glucose metabolism parameters. However, the role and contribution of adiposity and glucose metabolism to the circulating visfatin levels in obese patients remain to be explored.

Keywords: Visfatin,Obese,insulin resistance,glucose tolerance test

Derya Taşkesen, Birgül Kirel, Tercan Us. Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents. J Clin Res Pediatr Endocrinol. 2012; 4(2): 76-81
Manuscript Language: English
LookUs & Online Makale