ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : Issue : Year : 2022
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Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
A novel mutation in the TRIP11 gene: Diagnostic approach from relatively common skeletal dysplasias to an extremely rare Odontochondrodysplasia [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-68077 | DOI: 10.4274/jcrpe.galenos.2021.2021.0099

A novel mutation in the TRIP11 gene: Diagnostic approach from relatively common skeletal dysplasias to an extremely rare Odontochondrodysplasia

Burcu Yeter1, Ayca Dilruba Aslanger2, Gözde Yesil2, Nursel H. Elcioglu1
1Department of Pediatric Genetics, Marmara University Medical School, Istanbul, Turkey
2Department of Medical Genetics, Istanbul University Faculty of Medicine, Istanbul, Turkey
3Eastern Mediterranean University Medical School, Famagusta, Mersin 10, Turkey

Odontochondrodysplasia (ODCD, OMIM #184260) is a quite rare non-lethal skeletal dysplasia characterized by involvement of the spine and
metaphyseal regions of the long bones, pulmonary hypoplasia, short stature, joint hypermobility, and dentinogenesis imperfecta. ODCD is
inherited in an autosomal recessive fashion with an unknown frequency caused by mutations of the thyroid hormone receptor interactor 11 gene (TRIP11; OMIM *604505). TRIP11 gene encodes the Golgi microtubule-associated protein 210 (GMAP-210), which is an indispensable protein for the function of the Golgi apparatus. Mutations of the TRIP11 gene also cause achondrogenesis type 1A (ACG1A). Null mutations of TRIP11 lead to ACG1A, also known as a lethal skeletal dysplasia, while hypomorphic mutations cause ODCD. Here we report a male child diagnosed as ODCD with a novel compound heterozygote mutation who presented with skeletal changes, short stature, dentinogenesis imperfecta, and facial dysmorphism resembling Achondroplasia (ACH) and Hypochondroplasia (HCH).

Keywords: Odontochondrodysplasia, TRIP11, skeletal dysplasia, dentinogenesis imperfecta, rare disease



Corresponding Author: Burcu Yeter, Türkiye
Manuscript Language: English
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