ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 4 Issue : 3 Year : 2024
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Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Increased Thrombin-Activatable Fibrinolysis Inhibitor and Decreased Tissue Factor Pathway Inhibitor and Thrombomodulin Levels in Children with Hypothyroidism [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2012; 4(3): 146-150 | DOI: 10.4274/Jcrpe.652

Increased Thrombin-Activatable Fibrinolysis Inhibitor and Decreased Tissue Factor Pathway Inhibitor and Thrombomodulin Levels in Children with Hypothyroidism

Bülent Alioğlu1, Nevin Kılıç2, Enver Şimşek3, Yıldız Dallar2
1The Ministry Of Health Of Turkey, Ankara Training And Research Hospital, Department Of Pediatric Hematology, Director Of The Hematology Laboratories, Ankara, Turkey
2The Ministry Of Health Of Turkey, Ankara Training And Research Hospital, Department Of Pediatrics, Ankara, Turkey
3The Ministry Of Health Of Turkey, Ankara Training And Research Hospital, Department Of Pediatric Endocrinology, Ankara, Turkey

Objective: We determined the profile of coagulation/fibrinolytic and vascular endothelial cell function parameters including plasminogen activator inhibitor (PAI) and thrombin-activatable fibrinolysis inhibitor (TAFI), tissue factor pathway inhibitor (TFPI), thrombomodulin (TM), and tissue plasminogen activator (tPA) levels in children with hypothyroidism.
Methods: Forty children with hypothyroidism aged 0-16 months who presented for the first time to our hospital and 29 age-and sex-matched healthy controls were enrolled in the study. All coagulation tests were performed with ELISA method. One year after Na-L-thyroxine treatment, the study parameters were re-evaluated in 25 euthyroid children out of the 40 patients diagnosed with hypothyroidism.
Results: Although no significant effect was detected regarding PAI antigen (Ag) and tPA Ag, the levels of TAFI, TM, and TFPI were consistent with subclinical hypercoagulability and hypofibrinolysis. There was a significant increase in TAFI Ag levels and a significant decrease in TFPI Ag and TM Ag levels in hypothyroid patients compared to healthy controls. As a result of correlation tests, the largest impact of hypothyroidism on coagulation system was on TFPI. In accordance with these findings, TAFI Ag levels decreased and TFPI Ag and TM Ag levels increased with hormonal replacement therapy.
Conclusions: Increased TAFI and decreased TFPI and TM in patients with hypothyroidism may indicate a potential hypercoagulable and hypofibrinolytic state as well as possible endothelial dysfunction, which may increase the risk of atherosclerotic and atherothrombotic complications. Thyroid hormone levels should also be checked in patients with a predisposition to coagulation, and thyroid replacement therapy should be initiated.

Keywords: hypothyroidism,thrombin-activatable fibrinolysis inhibitor,tissue factor pathway inhibitor,thrombomodulin

Bülent Alioğlu, Nevin Kılıç, Enver Şimşek, Yıldız Dallar. Increased Thrombin-Activatable Fibrinolysis Inhibitor and Decreased Tissue Factor Pathway Inhibitor and Thrombomodulin Levels in Children with Hypothyroidism. J Clin Res Pediatr Endocrinol. 2012; 4(3): 146-150
Manuscript Language: English
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