ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : Issue : Year : 2024
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Turkish Society for Pediatric Endocrinology and Diabetes
Association of DENND1A Gene Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2016; 8(2): 135-143 | DOI: 10.4274/jcrpe.2259

Association of DENND1A Gene Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis

Shan Bao1, Jun-Hong Cai2, Shu-Ying Yang1, Yongchao Ren3, Tian Feng4, Tianbo Jin3, Zhuo-Ri Li5
1Hainan Provincial People’S Hospital, Clinic Of Gynecology And Obstetrics, Haikou, China
2Hainan Provincial People’S Hospital, Central Laboratory, Haikou, China
3Northwest University School of Life Sciences, Shaanxi, China
4National Engineering Research Center for Miniaturized Detection Systems, Shaanxi, China
5Hainan Provincial People’s Hospital, Clinic of Gynecology and Obstetrics, Haikou, China

Objective: The rs2479106 and rs10818854 polymorphisms in the DENND1A gene have been reported to be extensively associated with risk of polycystic ovary syndrome (PCOS). However, the results from these studies remained inconclusive and conflicting. To detect a true association of rs2479106 and rs10818854 polymorphisms with PCOS risk, a single study may be underpowered, particularly for those studies with inadequate sample size. Therefore, we performed a meta-analysis of all available studies to explore this association.
Methods: All studies published up to March 2015 on the association were identified by searching electronic databases PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure. Studies containing available genotype frequencies of those 2 polymorphisms were chosen, and the odds ratios and associated 95% confidence intervals were calculated using fixed- or random- effects models.
Results: A total of 8 studies about s2479106 polymorphism (8185 cases and 28675 controls) and 5 studies about rs10818854 polymorphism (6638 cases and 27443 controls) met the inclusion criteria for the meta-analysis. Overall, significant increase of PCOS risk was found between DENND1A-rs10818854 and PCOS susceptibility. In addition, we also found an increased risk of PCOS in rs2479106 allele model, heterozygote variant genetic model, and dominant genetic model.
Conclusion: This meta-analysis suggested that rs2479106 and rs10818854 polymorphisms in the DENND1A gene were associated with increased risk of PCOS. To validate the association between these polymorphisms and PCOS susceptibility, further large and well-designed studies are needed.

Keywords: Polycystic ovary syndrome,DENND1A,rs2479106,rs10818854,meta-analysis

Shan Bao, Jun-Hong Cai, Shu-Ying Yang, Yongchao Ren, Tian Feng, Tianbo Jin, Zhuo-Ri Li. Association of DENND1A Gene Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis. J Clin Res Pediatr Endocrinol. 2016; 8(2): 135-143
Manuscript Language: English
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