ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 15 Issue : 4 Year : 2023
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Turkish Society for Pediatric Endocrinology and Diabetes
Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2023; 15(4): 421-425 | DOI: 10.4274/jcrpe.galenos.2022.2021-8-14

Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma

Ha Nguyen Thi1, Cuong Pham Manh2, TuanLinh To3, Le Thi Lan Anh1, Nam Nguyen Thanh4, Soamarat Vilaiyuk5
1Hanoi Medical University, Bach Mai Hospital, Clinic of Pediatrics, Hanoi, Vietnam
2Bach Mai Hospital, Diagnostic Imaging Central, Hanoi, Vietnam
3Viet Duc Hospital, Maxillofacial, Department of Plastic and Aesthetic Surgery, Hanoi, Vietnam
4Bach Mai Hospital, Clinic of Pediatrics, Hanoi, Vietnam
5Mahidol University Faculty of Medicine; Ramathibodi Hospital, Department of Pediatrics, Division of Rheumatology, Bangkok, Thailand

Tumor-induced osteomalacia (TIO) is a rare, paraneoplastic disorder of hypophosphatemia associated with elevated tumor-produced fibroblast growth factor 23 (FGF23). Maxillofacial tumors are rarely involved in TIO, especially maxillary TIO in children. We present a 14-year-old boy with osteomalacia and high serum levels of FGF23, a hormone associated with decreased phosphate resorption, due to a maxillary tumor. The patient was treated with oral phosphorus and calcitriol, and surgical removal of the tumor was performed. After 21 months follow-up, he was pain free and had returned to full activity. We review the reported pediatric cases of TIO in the maxillofacial and oral region and discuss the management of these patients considering the published evidence.

Keywords: Tumor-induced osteomalacia, fibroblast growth factor-23, maxilla, children

Ha Nguyen Thi, Cuong Pham Manh, TuanLinh To, Le Thi Lan Anh, Nam Nguyen Thanh, Soamarat Vilaiyuk. Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma. J Clin Res Pediatr Endocrinol. 2023; 15(4): 421-425

Corresponding Author: Ha Nguyen Thi, Vietnam
Manuscript Language: English
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