Autoimmune Polyglandular Syndrome Type 2: A Rare Condition in Childhood
Heves Kırmızıbekmez1, Rahime Gül Yeşiltepe Mutlu1, Nafiye Demirkıran Urgancı2, Ayşe Öner31Zeynep Kamil Obstetrics And Children Education And Research Hospital, Clinic Of Pediatric Endocrinology, İstanbul, Turkey 2Şişli Etfal Education And Research Hospital, Clinic Of Pediatric Gastroenterology, İstanbul, Turkey 3Academic Hospital, Clinic Of Pediatric Nephrology And Rheumatology, İstanbul, Turkey
Autoimmune polyglandular syndrome type 2 is defined as the occurrence of Addison’s disease concomitantly with autoimmune thyroid disease and/or type 1 diabetes mellitus. An 11-year-old boy with Hashimoto’s disease, Addison’s disease, celiac disease and Langerhans islet cell autoimmunity is described in this case report. Treatment of an endocrine disease may also trigger the onset of another endocrine disease. This case report underlines the importance of early recognition and treatment of critical endocrine diseases as well as the necessity to investigate pediatric patients with autoimmune diseases for coexisting conditions. Furthermore, the role of psychological stress as an inducer of autoimmunity was also discussed.