ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 4 Issue : 4 Year : 2024
Forms

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Trends in the Frequency of HLA DR-DQ Haplotypes Among Children and Adolescents with Type 1 Diabetes Mellitus in the Southeast Region of Turkey [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2012; 4(4): 189-192 | DOI: 10.4274/Jcrpe.768

Trends in the Frequency of HLA DR-DQ Haplotypes Among Children and Adolescents with Type 1 Diabetes Mellitus in the Southeast Region of Turkey

Mehmet Keskin1, Ayşe Aygün2, Sacide Pehlivan3, Özlem Keskin2, Yılmaz Kor1, Ayşe Balat2, Yavuz Coşkun2
1Gaziantep University Faculty Of Medicine, Department Of Pediatric Endocrinology And Metabolisms, Gaziantep, Turkey
2Gaziantep University Faculty Of Medicine, Department Of Pediatrics, Gaziantep, Turkey
3Gaziantep University Faculty Of Medicine, Department Of Medical Biology, Gaziantep, Turkey

Objective: The aim of this study was to determine the frequency of HLA DR-DQ haplotypes in children with type 1 diabetes mellitus (T1DM) in the Southeast Region of Turkey.
Methods: Eighty children and adolescents with T1DM and eighty control subjects participated in the study. HLA-DR, DQ was typed using polymerase chain reaction and sequence-specific priming technique.
Results: HLA DRB1*03 allele was significantly more common in patients than in control subjects. HLA DRB1*11, HLA DRB1*13 and HLA DRB1*14 allele frequencies were significantly lower in patients than in controls. DQB1*02 allele was more common in patients, whereas DQB1*03 allele was more frequent in control subjects. HLA DRB1*03-DQB1*02 haplotype was more frequently observed among patients.
Conclusion: These results confirm the similar potential trends in the frequency distribution of HLA susceptibility genes with T1DM previously observed in Turkey and in other Caucasian populations.

Keywords: type 1 diabetes mellitus,HLA DR-DQ haplotype,allele,children,Autoimmunity

Mehmet Keskin, Ayşe Aygün, Sacide Pehlivan, Özlem Keskin, Yılmaz Kor, Ayşe Balat, Yavuz Coşkun. Trends in the Frequency of HLA DR-DQ Haplotypes Among Children and Adolescents with Type 1 Diabetes Mellitus in the Southeast Region of Turkey. J Clin Res Pediatr Endocrinol. 2012; 4(4): 189-192
Manuscript Language: English
LookUs & Online Makale