J Clin Res Pediatr Endocrinol. 2019; 11(3): 311-318 | DOI: 10.4274/jcrpe.galenos.2018.2018.0204
Magnesium and Anti-phosphate Treatment with Bisphosphonates for Generalised Arterial Calcification of Infancy: A Case Report
Fatma Dursun1, Tülay Atasoy Öztürk2, Serçin Güven3, Heves Kırmızıbekmez1, Gülcan Seymen Karabulut1, Sevinç Kalın2, Betül Sözeri41Ümraniye Training and Research Hospital, Clinic of Pediatric Endocrinology, İstanbul, Turkey
2Ümraniye Training and Research Hospital, Clinic of Radiology, İstanbul, Turkey
3Ümraniye Training and Research Hospital, Clinic of Pediatric Nephrology, İstanbul, Turkey
4Ümraniye Training and Research Hospital, Clinic of Pediatric Rheumatology, İstanbul, Turkey
Generalized arterial calcification of infancy (GACI) is a rare autosomal-recessive disorder, characterized by calcification of the internal elastic lamina, fibrotic myointimal proliferation of muscular arteries and resultant arterial stenosis. Treatment with bisphosphonates has been proposed as a means of reducing arterial calcifications in GACI patients, although there is no formalized treatment approach. The case reported here was a patient with severe GACI diagnosed at three months of age who had no response to bisphosphonate treatment, but clinically improved after the initiation of magnesium and anti-phosphate (using calcium carbonate) treatments. In patients unresponsive to bisphosphonate, magnesium and anti-phosphate treatment may be attempted.
Keywords: Generalized arterial calcification, infant, treatment, magnesium, etidronate
Fatma Dursun, Tülay Atasoy Öztürk, Serçin Güven, Heves Kırmızıbekmez, Gülcan Seymen Karabulut, Sevinç Kalın, Betül Sözeri. Magnesium and Anti-phosphate Treatment with Bisphosphonates for Generalised Arterial Calcification of Infancy: A Case Report. J Clin Res Pediatr Endocrinol. 2019; 11(3): 311-318
Manuscript Language: English