ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 8 Issue : 2 Year : 2024
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Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Neonatal Thyroid-Stimulating Hormone Screening as a Monitoring Tool for Iodine Deficiency in Turkey [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2016; 8(2): 187-191 | DOI: 10.4274/jcrpe.2526

Neonatal Thyroid-Stimulating Hormone Screening as a Monitoring Tool for Iodine Deficiency in Turkey

Nilgün Çaylan1, Başak Tezel1, Sema Özbaş1, Nuran Şahin1, Şirin Aydın1, Deniz Acıcan1, Bekir Keskinkılıç2
1Public Health Institution Of Turkey, Department Of Child And Adolescent Health, Ankara, Turkey
2Public Health Institution Of Turkey, Non-Communicable Diseases And Cancer Vice Presidency, Ankara, Turkey

Objective: Thyroid-stimulating hormone (TSH) level in neonates is recommended as an indicator for presence of iodine deficiency (ID) at a population level and as a monitoring tool in programs of iodine supplementation. The purpose of this study, based on data from the National Newborn Screening Program (NNSP) for congenital hypothyroidism (CH) in 2014, was to analyze neonatal TSH levels to predict the current status of iodine nutrition in Turkey.
Methods: According to screening methodology, heel-prick blood samples of newborns were collected on filter paper cards usually on day 3-5 after birth (or shortly before discharge). Results of samples collected >48 h after birth were analyzed. The degree of severity of ID was assessed by using the epidemiologic criteria of the World Health Organization (WHO). Elevated TSH levels (>5 mIU/L) were processed and classified according to province, region, birth season, and sampling time.
Results: A total of 1,298531 newborns were registered in the NNSP for the CH database. Of those, 1,270311 newborns had screening results collected >48 h after birth and were included in the statistical analyses. The national prevalence of elevated TSH was 7.2%. While the Gaziantep sub-region had the highest TSH elevation rate (15.9%), the Tekirdağ sub-region had the lowest rate (4.0%; p<0.001). Seasonal variations were also significant, and the elevated TSH prevalence rate was highest in winter (7.4%; p<0.001).
Conclusion: National CH screening results suggest that Turkey may still be mildly iodine deficient. Nationwide studies should be performed for direct assessment and monitoring of iodine status in vulnerable populations to confirm accuracy of our results.

Keywords: Thyroid-stimulating hormone,screening program,Turkey,newborn

Nilgün Çaylan, Başak Tezel, Sema Özbaş, Nuran Şahin, Şirin Aydın, Deniz Acıcan, Bekir Keskinkılıç. Neonatal Thyroid-Stimulating Hormone Screening as a Monitoring Tool for Iodine Deficiency in Turkey. J Clin Res Pediatr Endocrinol. 2016; 8(2): 187-191
Manuscript Language: English
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