Renal Anomalies Associated with Ectopic Neurohypophysis
Samim Özen1, Damla Gökşen Şişmek2, Asan Önder3, Şükran Darcan21Pediatric Endocrinology Unit, Mersin Children Hospital, Toroslar, Mersin, Turkey 2Department Of Pediatric Endocrinology And Metabolism, Ege University School Of Medicine, Izmir, Turkey 3Department Of Pediatrics, Ege University School Of Medicine, Izmir, Turkey
Objective: Although the etiology of ectopic neurohypophysis that leads to pituitary hormone deficiencies is not yet clearly understood, birth trauma or genetic factors have been considered responsible. Concurrent cranial and extracranial congenital anomalies have been reported in such cases. The aim of the present study was to investigate the frequency of renal anomalies in nonsyndromic cases with ectopic neurohypophysis. Methods: We retrospectively evaluated the medical records of 20 patients with ectopic neurohypophysis who were followed up between January 1990 and December 2007 in a tertiary University Hospital. Results: Renal anomalies were identified in three (15%) cases including unilateral renal agenesis in one case, renal hypoplasia in one case, and double collecting system and unilateral renal agenesis in one case. Conclusions: In the present study, the increased frequency of renal anomalies in cases of ectopic neurohypophysis was highlighted, and it was emphasized that there might be common genetic factors that lead to such associations.