J Clin Res Pediatr Endocrinol. 2014; 6(3): 177-179 | DOI: 10.4274/jcrpe.1383
Unusual Course of Congenital Hypothyroidism and Route of the L-Thyroxine Treatment in a Preterm Newborn
Levent Korkmaz1, Mustafa Ali Akın2, Tamer Güneş1, Ghaniya Daar3, Osman Baştuğ1, Ali Yıkılmaz4, Selim Kurtoğlu11Erciyes University Faculty Of Medicine, Neonatology, Kayseri, Turkey
2Kayseri Training And Research Hospital, Neonatology Unit, Kayseri, Turkey
3Bozok University Faculty Of Medicine, Department Of Pediatrics, Yozgat, Turkey
4Erciyes University Faculty Of Medicine, Department Of Radiology, Kayseri, Turkey
Congenital hypothyroidism (CH) is the most common endocrine pathology in neonates. Inappropriate treatment of CH is complicated by irreversible brain damage or low IQ score. Hormone replacement therapy with L-thyroxine (L-T4) is sufficient for a very large proportion of patients. However, during treatment, the patient needs to be carefully monitored for presence of factors which might affect the absorption or bio-availability of the drug as well as its dose. Herein, we report a preterm newborn with CH who presented with gastrointestinal problems mimicking necrotizing enterocolitis. The clinical course was also complicated by cholestasis. The L-T4 replacement treatment was switched from oral route to parenteral. After resolution of the cholestasis, L-T4 treatment was continued successfully by the oral route.
Keywords: congenital hypothyroidism,L-thyroxine,prematurity
Levent Korkmaz, Mustafa Ali Akın, Tamer Güneş, Ghaniya Daar, Osman Baştuğ, Ali Yıkılmaz, Selim Kurtoğlu. Unusual Course of Congenital Hypothyroidism and Route of the L-Thyroxine Treatment in a Preterm Newborn. J Clin Res Pediatr Endocrinol. 2014; 6(3): 177-179
Manuscript Language: English